Peripheral Neuropathy Research

The Use of Shock Waves in Peripheral Nerve Regeneration: New Perspectives?

“Low-energy extracorporeal shock wave treatment (ESWT) is a relatively new therapeutic tool that is widely used for the treatment of epicondylitis and plantar fasciitis and to foster bone and wound healing. Shock waves, sonic pulses with high energy impact, are thought to induce biochemical changes within the targeted tissues through mechanotransduction. The biological effects of ESWT are manifested in improved vascularization, the local release of growth factors, and local anti-inflammatory effects, but the target cells too are influenced. ESWT appears to have differential effects on peripheral nerves and has been proved to promote axonal regeneration after axotomy.

ESWT may augment and potentiate the mechanisms described earlier in a regenerating nerve segment.  It is to be expected that ESWT will become more widely used in the treatment of injuries and pathological conditions affecting peripheral nerves.”

Hausner, T., & Nógrádi, A. (2013). The Use of Shock Waves in Peripheral Nerve Regeneration: New Perspectives? International Review of Neurobiology, 109, 85-98. doi:10.1016/c2009-0-01809-1

Efficacy of Extracorporeal Shockwaves Therapy on Peripheral Nerve Regeneration

Purpose: This study was conducted to determine the effects of different doses and methods of extracorporeal shock wave treatment (ESWT) on the sciatic nerve regeneration… using unbiased quantitative stereological techniques and to know which method and dose were effective.

Results: There is a variable increase in the axon numbers among the shockwave treated groups in compare to the control group. The focused groups showed better improvement and the 300-focused group has shown the highest regeneration rate.

Conclusion: The authors found that ESWT promotes nerve regeneration, increases the thickness of the myelin sheath and that the most effective result is in the 300 shock wave.”

Sağir, D., Bereket, C., Onger, M. E., Bakhit, N., Keskin, M., & Ozkan, E. (2019). Efficacy of Extracorporeal Shockwaves Therapy on Peripheral Nerve Regeneration. Journal of Craniofacial Surgery, 30(8), 2635-2639. doi:10.1097/scs.0000000000005671

Extracorporeal shock wave therapy effectively prevented diabetic neuropathy

“In vitro and invivo studies showed that extracorporeal shockwave (ECSW) treatment inhibited inflammation as  well as reactive oxygen species generation and oxidative stress.  ECSW therapy  protected the sciatic nerve from diabetic neuropathy.  In conclusion, the results of the present study demonstrated that ECSW treatment effectively ameliorated diabetic neuropathy in a murine experimental setting.”

Chen, Yi-Ling, Chen, Kuan-Hung, Yin, Tsung-Chen, et al. (2015). Extracorporeal shock wave therapy effectively prevented diabetic neuropathy American Journal of Translational Research, ISSN:1943-8141/AJTR0017386

Extracorporeal shock wave therapy effectively prevented diabetic neuropathy

“The Team of the Ludwig Boltzmann Institute for experimental and clinical traumatology impressively demonstrated that Spark Wave Therapy enhances peripheral nerve regeneration and has great optimizing potential for surgical treatment after peripheral nerve injuy in future.

 Spark Wave Therapy, A New Method for Peripheral Nerve Regeneration

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